Translating Axon Guidance Cues
نویسنده
چکیده
Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery that would allow the local synthesis of receptors for axon guidance cues.
منابع مشابه
Axon response to guidance cues is stimulated by acetylcholine in Caenorhabditis elegans.
Gradients of acetylcholine can stimulate growth cone turning when applied to neurons grown in culture, and it has been suggested that acetylcholine could act as a guidance cue. However, the role acetylcholine plays in directing axon migrations in vivo is not clear. Here, we show that acetylcholine positively regulates signaling pathways that mediate axon responses to guidance cues in Caenorhabd...
متن کاملAxon response to guidance cues is stimulated by acetylcholine in C. elegans
Gradients of acetylcholine can stimulate growth cone turning when applied to neurons grown in culture and it has been suggested that acetylcholine could act as a guidance cue. However, the role acetylcholine plays in directing axon migrations in vivo is not clear. Here, we show that acetylcholine positively regulates signaling pathways that mediate axon responses to guidance cues in Caenorhabdi...
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Morphogen family proteins are now widely appreciated as axon guidance cues. Because their roles as morphogens are highly conserved across phylogeny, their functional conservation in axon guidance is now being rigorously examined. Recent studies suggest that morphogens are important in shaping topographic projections in chick and Drosophila visual systems, a process that occurs even later in dev...
متن کاملThe growth cone: an integrator of unique cues into refined axon guidance
One of the challenges to understanding nervous system development is to establish how a fairly limited number of axon guidance cues can set up the patterning of very complex nervous systems. Most of the recent insights relevant to guidance mechanisms have come from cell biologists focusing on processes and molecular machinery controlling the guidance responses in the growth cone.
متن کاملConcentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues.
Formation of functional motor circuits relies on the ability of distinct spinal motor neuron subtypes to project their axons with high precision to appropriate muscle targets. While guidance cues contributing to motor axon pathfinding have been identified, the intracellular pathways underlying subtype-specific responses to these cues remain poorly understood. In particular, it remains controver...
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عنوان ژورنال:
- Cell
دوره 110 شماره
صفحات -
تاریخ انتشار 2002